The best replacement for sikuli is eggplant.

The best alternatives to sikuli are rated as following:
★★★★★  eggplant
★★★★★  autoit
★★★★  autohotkey
★★★  sikuli
★★★  ranorex

Your alternative for sikuli is not listed? Suggest!
Speaking about sikuli, one probably shouldn't forget about robot framework.

Other search terms related to sikuli and their ratings are:
★★★★★ robot framework
You have in mind a companion for sikuli and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of sikuli in all years. Click on graph for more.
sikuli
eggplant
autoit