The best replacement for autohotkey is autoit.

The best alternatives to autohotkey are rated as following:
★★★★★  autoit
★★★  phraseexpress
★★★  autohotkey_l
★★  launchy
★★  texter
★★  hotkeynet
★★  sikuli
★★  macro express
★  eventghost
★  sharpkeys
★  activewords
  keyclone
  jitbit

Your alternative for autohotkey is not listed? Suggest!
Speaking about autohotkey, one probably shouldn't forget about gui.

Other search terms related to autohotkey and their ratings are:
★★★★★ gui
★★ samp
You have in mind a companion for autohotkey and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of autohotkey in all years. Click on graph for more.
autohotkey
autoit
phraseexpress