The best replacement for wxpython is tkinter.

The best alternatives to wxpython are rated as following:
★★★★★  tkinter
★★★★★  pyqt
★★★  pygtk
★★  pygame
★★  gtk
★  wxwidgets
★  kivy
★  pyside
  glade
  tk

Your alternative for wxpython is not listed? Suggest!
Speaking about wxpython, one probably shouldn't forget about matplotlib.

Other search terms related to wxpython and their ratings are:
★★★★★ matplotlib
★★★★ pygame
★★ py2exe
You have in mind a companion for wxpython and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of wxpython in all years. Click on graph for more.
wxpython
tkinter
pyqt