The best replacement for wits end is nashor's tooth.

The best alternatives to wits end are rated as following:
★★★★★  nashor's tooth
★★★★  botrk
★★★★  malady
★★★★  ionic spark
★★  maw of malmortius
★★  wit's end
★★  whits end
★★  madreds
★  zephyr
★  hexdrinker
  maw

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wits end
nashor's tooth
botrk