The best replacement for tuneup utilities is system mechanic.

The best alternatives to tuneup utilities are rated as following:
★★★★★  system mechanic
★★★★  ccleaner
★★  winutilities
★★  advanced systemcare
★  advanced system care
★  advanced system optimizer
★  registry mechanic
★  avg pc tuneup
★  glary utilities
★  avg tuneup
★  uniblue
★  windows 7 manager
  diskeeper
  ace utilities
  slimcleaner
  powersuite
  glary
  auslogics boostspeed
  advance system optimizer
  speedupmypc

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Google Trends

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tuneup utilities
system mechanic
ccleaner