The best replacement for tumour is tumor.

The best alternatives to tumour are rated as following:
★★★★★  tumor
★★★★  cyst
★★★  lesion
★  aneurysm
★  tension headache
  carcinoma
  fibroadenoma
  neuroblastoma

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No companions for tumour have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of tumour in all years. Click on graph for more.
tumour
tumor
cyst