The best replacement for lesion is tumor.

The best alternatives to lesion are rated as following:
★★★★★  tumor
★★★★  cyst
★★  ulcer
★★  nodule
★  lower motor neuron lesion
★  sore
★  neoplasm
★  tumour
★  abscess
★  malignancy
★  abrasion
★  bruise
★  lmn lesion
★  ablation
  laceration
  brain tumor
  polyp
  tumor brain
  tear
  wound
  alpsa
  lower
  cyst kidney
  bankart lesion
  adhesion
  slap tear
  hill sachs lesion

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No companions for lesion have been suggested so far.
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Google Trends

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lesion
tumor
cyst