The best replacement for symptom is sign.

The best alternatives to symptom are rated as following:
★★★★★  sign
★★★★★  problem
★★★★  cause
★★  root cause
★★  side effect
★★  disease
★  syndrome
★  clinical sign
  progesterone side effect
  manifestation
  cold symptom
  pregnancy symptom
  signs

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Google Trends

Scale is based on the average worldwide traffic of symptom in all years. Click on graph for more.
symptom
sign
problem