The best replacement for side effect is adverse effect.

The best alternatives to side effect are rated as following:
★★★★★  adverse effect
★★★★  adverse reaction
★★  side effect
★★  allergy
★★  allergic reaction
★★  side affect
★★  affect
★★  adverse drug reaction
★★  adverse event
  reaction
  symptom
  bwf
  adr
  adverse effects

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side effect
adverse effect
adverse reaction