The best replacement for sedative is tranquilizer.

The best alternatives to sedative are rated as following:
★★★★★  tranquilizer
★★★★★  hypnotic
★★  narcotic
★  anesthetic
★  hypnotics
★  stimulant
★  depressant
  sedative hypnotic
  anxiolytic
  tranquilizers

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Google Trends

Scale is based on the average worldwide traffic of sedative in all years. Click on graph for more.
sedative
tranquilizer
hypnotic