The best replacement for sampler is synthesizer.

The best alternatives to sampler are rated as following:
★★★★★  synthesizer
★★★  simpler ableton
★★  simpler
★★  drum machine
★★  profiler
★★  synth
★  kontakt
★  rompler
★  sequencer
  midi controller
  kontakt ableton

Your alternative for sampler is not listed? Suggest!
Speaking about sampler, one probably shouldn't forget about free humidor.

Other search terms related to sampler and their ratings are:
★★★★★ free humidor
★★★ drum machine
You have in mind a companion for sampler and it is not yet here? Propose!



Google Trends

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sampler
synthesizer
simpler ableton