The best replacement for synthesizer is keyboard.

The best alternatives to synthesizer are rated as following:
★★★★★  keyboard
★★★★★  workstation
★★★★  digital piano
★★★  midi controller
★★★  piano
★★  midi
★  arranger
★  sampler
★  electric piano
★  keyboard workstation
  hardware
  midi keyboard
  digital synthesizer
  autotune
  organ
  synthesiser
  controller
  stage piano
  work station
  keyboards

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Google Trends

Scale is based on the average worldwide traffic of synthesizer in all years. Click on graph for more.
synthesizer
keyboard
workstation