The best replacement for pure is applied research.

The best alternatives to pure are rated as following:
★★★★★  applied research
★★★  applied math
★★  applied mathematics
★  raw honey
★  mixture
★  sonos
★  bootstrap
★  virgin olive oil
★  applied
★  comfort zone
★  main
★  applied chemistry
★  tinder
★  extra virgin olive oil
  genesis
  xtremio
  imitation vanilla extract
  heat surge
  norton 360
  new phyrexia
  advocare
  ridge racer
  virgin coconut oil
  internet security
  iheater
  htc tilt 2
  motorstorm
  dark ghd
  tank
  artificial vanilla extract

Your alternative for pure is not listed? Suggest!
Speaking about pure, one probably shouldn't forget about addy gloves.

Other search terms related to pure and their ratings are:
★★★★★ addy gloves
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Google Trends

Scale is based on the average worldwide traffic of pure in all years. Click on graph for more.
pure
applied research
applied math