The best replacement for powerpoint is keynote.

The best alternatives to powerpoint are rated as following:
★★★★★  keynote
★★★  word
★★★  prezi
★★★  flash
★★  280 slides
★★  acrobat.com presentations
★★  pdf
★★  impress
★  powerpoint viewer
★  powerpoint
★  visio
★  google presentation
★  indesign
★  prezi pros and cons
★  word processing
★  publisher
★  word processed document
  hyperstudio
  word processing presentation
  inspiration
  beamer
  whiteboard
  slideshow
  power point
  word document
  microsoft word
  imovie
  movie maker
  openoffice
  remington corelokt
  pdf presentation
  core lokt
  propresenter
  ms word
  openoffice impress
  smartboard

Your alternative for powerpoint is not listed? Suggest!
Speaking about powerpoint, one probably shouldn't forget about audio.

Other search terms related to powerpoint and their ratings are:
★★★★★ audio
★★★★★ notes
★★★ animation
★★ microsoft
★★ powerpoint
★★ voice over
★ narration
★ speaker notes
visual basic
timeline
embedded video
You have in mind a companion for powerpoint and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of powerpoint in all years. Click on graph for more.
powerpoint
keynote
word