The best replacement for painter is photoshop.

The best alternatives to painter are rated as following:
★★★★★  photoshop
★★★  illustrator
★★★  artist
★★  sketchbook pro
★★  artrage
★★  sai
★★  painter
★  sweatt
★  paintor
★  sculptor
★  adobe photoshop
★  manga studio
★  calligrapher age of wushu
★  open canvas
★  painter lite
★  paint shop pro
  bannister
  photographer
  painter essentials
  sketchbook
  paint tool sai
  pencil artist
  opencanvas
  crean
  corel draw
  adobe illustrator
  tracking computer
  sweat
  artists

Your alternative for painter is not listed? Suggest!
Speaking about painter, one probably shouldn't forget about wacom.

Other search terms related to painter and their ratings are:
★★★★★ wacom
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Google Trends

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painter
photoshop
illustrator