The best replacement for nonsense is missense mutation.

The best alternatives to nonsense are rated as following:
★★★★★  missense mutation
★★★  missense mutations
★★★  nonsense
★★  missense
★★  rubbish
★★  senseless
★  nuisance
★  nonsensical
  non sense
  no nonsense
  non-sense

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Speaking about nonsense, one probably shouldn't forget about nonsense.

Other search terms related to nonsense and their ratings are:
★★★★★ nonsense
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Google Trends

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nonsense
missense mutation
missense mutations