The best replacement for neoprene is nitrile.

The best alternatives to neoprene are rated as following:
★★★★★  nitrile
★★★★★  epdm
★★★★  rubber
★★★  breathable waders
★★  thinsulate
★★  buna
★★  nitrile gloves
★  viton
★  natural rubber
★  polyurethane
★  lycra
★  membrane drysuit
★  neosupreme
★  membrane
★  santoprene
★  breathable
  polychloroprene
  trilaminate
  latex seals
  polyisoprene
  nitrile rubber
  leatherette
  hypalon
  ensolite
  polyurethane foam

Your alternative for neoprene is not listed? Suggest!
Speaking about neoprene, one probably shouldn't forget about neoprene.

Other search terms related to neoprene and their ratings are:
★★★★★ neoprene
You have in mind a companion for neoprene and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of neoprene in all years. Click on graph for more.
neoprene
nitrile
epdm