The best replacement for midwest is east coast.

The best alternatives to midwest are rated as following:
★★★★★  east coast
★★★★  midwest
★★★★  west coast
★★★★  south
★★★★  northeast
★★★  northern brewer
★  mideast
★  southwest
★  east coast attitude
★  airtran
★  frontier
  great plains
  pacific northwest

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Google Trends

Scale is based on the average worldwide traffic of midwest in all years. Click on graph for more.
midwest
east coast
midwest