The best replacement for mewtwo is mew.

The best alternatives to mewtwo are rated as following:
★★★★★  mew
★★★★  arceus
★★★★  deoxys
★★★  lucario
★★★  lugia
★★  darkrai
★★  alakazam
★  frieza
★  rayquaza
★  charizard
★  mega charizard
★  vegeta
★  zygarde masterball
★  zapdos
★  arceus stronger
  pikachu
  genesect
  giratina
  yveltal
  kadabra
  shadow
  mewtwo
  espeon
  mew movie
  xerneas
  suicune
  dialga
  lucarrio
  arceus unstoppable
  magikarp
  mew pokemon movie
  gary
  arcues
  mewthree

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Google Trends

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mewtwo
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