The best replacement for mesalamine is sulfasalazine.

The best alternatives to mesalamine are rated as following:
★★★★★  sulfasalazine
★★★  balsalazide
★★★  mesalazine
★★  pentasa
★  asacol
★  lialda
★  budesonide
★  olsalazine

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mesalamine
sulfasalazine
balsalazide