The best replacement for mdaemon is kerio.

The best alternatives to mdaemon are rated as following:
★★★★★  kerio
★★★★★  zimbra
★★★★  exchange
★★★  exchange 2010
★★★  mailenable
★★★  exchange 2013
★★  icewarp
★★  kerio connect
★★  smartermail
★  microsoft exchange
★  exchange server
★  ms exchange
★  imail
★  hmailserver
★  exchange 2003

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mdaemon
kerio
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