The best replacement for kerio is exchange.

The best alternatives to kerio are rated as following:
★★★★★  exchange
★★★  zimbra
★★  online armor
★★  mdaemon
★★  sygate
★★  zonealarm
★★  icewarp
★  outpost
★  zone alarm
★  smartermail
  axigen
  merak

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Google Trends

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kerio
exchange
zimbra