The best replacement for italics is quotation marks.

The best alternatives to italics are rated as following:
★★★★★  quotation marks
★★★★★  quotes
★★★  underline
★★  underlining
★★  quotations
★  quotes mla
★  bold
★  underline book titles
★  quotes book title
★  cursive
  quotes apa
  underline titles
  quotation
  quotes for titles
  underline book title
  italic
  underline mla
  emphasis
  italics
  quote marks
  quotes for book titles
  parentheses
  bold for movie titles

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Google Trends

Scale is based on the average worldwide traffic of italics in all years. Click on graph for more.
italics
quotation marks
quotes