The best replacement for e350 is e550.

The best alternatives to e350 are rated as following:
★★★★★  e550
★★★  535i
★★★  a6
★★  e500
★★  c300
★★  bmw 530
★★  c350
★★  e450
★★  gs350
★★  530i
★  ml350
★  s550
★  528i
★  f350
★  cls550
★  5 series
★  c50
★  bmw 530i
★  e250
★  m35
★  bmw 535
★  1037u
★  audi a6
★  bmw 5 series
  bmw 535i
  lexus gs350
  m37
  528
  bmw 528 535
  2007 bmw 530
  mercedes e350
  e320
  jaguar xf
  535
  3500 express

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Google Trends

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e350
e550
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