The best replacement for e250 is e350.

The best alternatives to e250 are rated as following:
★★★★★  e350
★★  528i
★★  e350 ford
★★  e150
★★  e220
★★  535d
★★  520d
★★  e350 mercedes
★  c250
★  express 2500
★  523i
★  e200
★  e300
★  ford e150
  520i

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e250
e350
528i