The best replacement for drug abuse is drug addiction.

The best alternatives to drug abuse are rated as following:
★★★★★  drug addiction
★★★  addiction
★★★  drug dependence
★★★  dependence
★★  drug misuse
★★  misuse
★  alcohol abuse
★  mental illness
  drug use
  use
  recreational use
  alcoholism
  substance abuse
  alcohol
  drug dependency

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No companions for drug abuse have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of drug abuse in all years. Click on graph for more.
drug abuse
drug addiction
addiction