The best replacement for 50 caliber is 20 mm.

The best alternatives to 50 caliber are rated as following:
★★★★★  20 mm
★★★★★  taliban
★★★★  44 magnum
★★★  338 lapua
★★  45 caliber
★★  mountain goat
★  20mm
★  prairie dog
  30 mm

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50 caliber
20 mm
taliban