The best replacement for 45 caliber is 9mm.

The best alternatives to 45 caliber are rated as following:
★★★★★  9mm
★★★★★  40 caliber
★★★  357
★★★  44 magnum
★★★  357 magnum
★  50 caliber
★  40
★  9 millimeter
  9 mm
  .44
  22 caliber
  10 mm
  .40
  44 caliber
  .38 caliber
  44
  357 caliber

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45 caliber
9mm
40 caliber