The best replacement for 4x12 is 2x12 cab.

The best alternatives to 4x12 are rated as following:
★★★★★  2x12 cab
★★★★★  4x10
★★★★★  3x9 scope
★★★★  1x12
★★★★  2x12
★★★  3x9
★★★  8x10
★★  2 2x12
★  two 2x12
★  2x15
★  2x12 guitar cabinet
★  4x8
★  2x12 orange
  marshall 4x12
  2x12 cabinet
  mesa
  4x10 cabinet
  8x12

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4x12
2x12 cab
4x10