The best replacement for 22-250 is 223.

The best alternatives to 22-250 are rated as following:
★★★★★  223
★★★★★  243
★★★★  204
★★  220 swift
★★  25-06
★★  204 ruger
★  270
★  223 ballistics
★  22 hornet
★  22lr
★  222
★  22
★  .223
  22 mag
  243 ballistics
  17 hmr
  .204

Your alternative for 22-250 is not listed? Suggest!
Speaking about 22-250, one probably shouldn't forget about 1 in 12 twist.

Other search terms related to 22-250 and their ratings are:
★★★★★ 1 in 12 twist
You have in mind a companion for 22-250 and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of 22-250 in all years. Click on graph for more.
22-250
223
243