The best replacement for rebif is avonex.

The best alternatives to rebif are rated as following:
★★★★★  avonex
★★★★★  copaxone
★★★  betaseron
★★  tysabri
★★  tecfidera
★★  gilenya
★  betaferon
★  aubagio
★  extavia
  bg-12
  avenox

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Google Trends

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rebif
avonex
copaxone