The best replacement for reason 5 is logic 9.

The best alternatives to reason 5 are rated as following:
★★★★★  logic 9
★★★  reason 6
★★★  ableton live 8
★★  reason 7
★★  ableton
★★  fl studio 9
★★  maschine
★  reason 4
★  ableton live
  fl studio 10
  komplete 7
  live 8

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reason 5
logic 9
reason 6