The best replacement for mbox 2 pro is digi 002.

The best alternatives to mbox 2 pro are rated as following:
★★★★★  digi 002
★★★★★  apogee duet
★★★★★  mbox 3
★★★★  mbox 2
★★★★  digi 003
★★★★  003
★★★  mbox 3 pro
★★  profire 610
★  mbox 3 mini
★  002
★  mbox 2 mini

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mbox 2 pro
digi 002
apogee duet