The best replacement for mastiff is bullmastiff.

The best alternatives to mastiff are rated as following:
★★★★★  bullmastiff
★★★★  rottweiler
★★★  great dane
★★★  english mastiff
★★★  bull mastiff
★★  coyote
★  st bernard
★  kangal
★  mastiff
★  german shepherd
★  cane corso
  newfoundland
  saint bernard
  cand cordon mastiff
  italian mastiff
  dude the chihuahua
  neapolitan mastiff
  tosa
  chihuahua
  bulldog
  great pyrenees
  american mastiff
  french mastiff
  presa canario

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Google Trends

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mastiff
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