The best replacement for great dane is mastiff.

The best alternatives to great dane are rated as following:
★★★★★  mastiff
★★★  irish wolfhound
★★★  doberman
★★  german shepherd
★★  rottweiler
★  english mastiff
★  boxer
★  weimaraner
★  labrador
★  cane corso
★  greyhound
★  american great dane
★  bullmastiff
  saint bernard
  bloodhound
  dalmatian
  european great dane
  newfoundland
  chihuahua
  male great dane

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great dane
mastiff
irish wolfhound