The best replacement for mass effect 2 is fallout 3.

The best alternatives to mass effect 2 are rated as following:
★★★★★  fallout 3
★★★  mass effect 1
★★★  dead space 2
★★★  uncharted 2
★★★  mass effect 3
★★★  dragon age
★★  fallout new vegas
★★  red dead redemption
★★  dragon age origins
★★  starcraft 2
★  bioshock 2
★  mass effect 3 graphics
★  mass effect
★  little big planet 2
★  two worlds 2
  dragon age 2
  witcher 2
  gears of war 2
  borderlands
  new vegas
  final fantasy 13
  god of war 3

Your alternative for mass effect 2 is not listed? Suggest!
Speaking about mass effect 2, one probably shouldn't forget about gamepad.

Other search terms related to mass effect 2 and their ratings are:
★★★★★ gamepad
★★★★★ texmod
★★★★ tali
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Google Trends

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mass effect 2
fallout 3
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