The best replacement for heartgard plus is interceptor.

The best alternatives to heartgard plus are rated as following:
★★★★★  interceptor
★★★★  sentinel
★★★★  heartgard
★★★  trifexis
★★  iverhart max
★★  iverhart plus
★★  heart shield plus
★★  tri heart plus
★  advantage multi
  nuheart
  iverhart
  pettrust plus
  tri heart
  tri-heart plus
  proheart

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heartgard plus
interceptor
sentinel