The best replacement for trifexis is sentinel.

The best alternatives to trifexis are rated as following:
★★★★★  sentinel
★★★★  comfortis
★★★  revolution
★★★  heartgard
★★  frontline
★  heartgard plus
★  capstar
★  interceptor
★  k9 advantix ii
★  iverhart
★  sentinel for dogs
★  nexgard
★  advantix
★  revolution for dogs
★  advantage multi for dogs
★  advantage multi
  comfortis which is better
  panoramis
  frontline plus
  heartguard
  k9 advantix
  revolution best for dogs
  vectra

Your alternative for trifexis is not listed? Suggest!
Speaking about trifexis, one probably shouldn't forget about frontline.

Other search terms related to trifexis and their ratings are:
★★★★★ frontline
★★★ advantix
★ ivermectin
★ capstar
★ tick collar
You have in mind a companion for trifexis and it is not yet here? Propose!



Google Trends

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trifexis
sentinel
comfortis