The best replacement for gts 450 is gtx 460.

The best alternatives to gts 450 are rated as following:
★★★★★  gtx 460
★★★★★  gtx 650
★★★★  gtx 260
★★★★  gt 640
★★★  gts 250
★★  gtx 550 ti
★★  gtx 650 ti
★★  hd 5770
★★  gt 630
★  gt 610
★  9800gtx
  9800 gt
  6670
  5670
  6770
  9800gt
  hd 5750

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gts 450
gtx 460
gtx 650