The best replacement for granisetron is ondansetron.

The best alternatives to granisetron are rated as following:
★★★★★  ondansetron
★★  palonosetron
★★  tropisetron
★  ramosetron

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Google Trends

Scale is based on the average worldwide traffic of granisetron in all years. Click on graph for more.
granisetron
ondansetron
palonosetron