The best replacement for palonosetron is ondansetron.

The best alternatives to palonosetron are rated as following:
★★★★★  ondansetron
★★★  granisetron
★  ramosetron
  aprepitant

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No companions for palonosetron have been suggested so far.
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Google Trends

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palonosetron
ondansetron
granisetron