The best replacement for giant defy is tcr.

The best alternatives to giant defy are rated as following:
★★★★★  tcr
★★★★  specialized roubaix
★★★  specialized allez
★★★  specialized secteur
★★  cannondale synapse
★★  roubaix
★  trek domane
★  trek 1.1
★  fuji roubaix
★  synapse
★  trek madone
★  cube peloton
★  trek 1.5
★  specialized tarmac
  trek 2.1
  giant tcr
  cannondale caad8
  cannondale caad9
  diamondback podium

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giant defy
tcr
specialized roubaix