The best replacement for cannondale synapse is specialized roubaix.

The best alternatives to cannondale synapse are rated as following:
★★★★★  specialized roubaix
★★★★  giant defy
★★★  trek madone
★★★  cervelo r3
★★★  specialized tarmac
★★★  specialized allez
★★★  trek domane
★★  scott cr1
★★  felt z5
★★  specialized ruby
★  specialized secteur
★  felt z85
★  cervelo rs
★  roubaix
  bianchi infinito

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