The best replacement for downtown is uptown.

The best alternatives to downtown are rated as following:
★★★★★  uptown
★★★  midtown atlanta
★★  suburbs
★★  midtown
★★  strip
★★  uptown charlotte
★★  downtown
★  midtown manhattan
★  uptown nyc
★  old montreal
★  down town
★  downton
★  south beach miami
★  malls
★  morning musume
★  city centre
★  midtown sacramento
  uptown dallas
  main campus
  vegas strip
  in downtown
  uptown amsterdam
  buckhead atlanta
  uptown flying pig
  brickell
  university of houston main campus
  new york downtown
  uptown new york
  hotel zone

Your alternative for downtown is not listed? Suggest!
Speaking about downtown, one probably shouldn't forget about uptown.

Other search terms related to downtown and their ratings are:
★★★★★ uptown
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Google Trends

Scale is based on the average worldwide traffic of downtown in all years. Click on graph for more.
downtown
uptown
midtown atlanta