The best replacement for defy advanced is tcr advanced.

The best alternatives to defy advanced are rated as following:
★★★★★  tcr advanced
★★★★★  roubaix
★★★★  cannondale synapse
★★★★  trek domane
★★  tcr
★  tcr composite
★  specialized roubaix
★  cervelo rs

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defy advanced
tcr advanced
roubaix