The best replacement for column chromatography is tlc.


The best alternatives to column chromatography are rated as following:
★★★★★  tlc
★★★  recrystallization
★★  thin layer chromatography
★★  flash chromatography
★★  hplc
★  distillation
★  paper chromatography
  gas chromatography
  gel electrophoresis

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Speaking about column chromatography, one probably shouldn't forget about tlc.

Other search terms related to column chromatography and their ratings are:

★★★★★ tlc
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column chromatography
tlc
recrystallization