The best replacement for cannondale supersix is specialized tarmac.

The best alternatives to cannondale supersix are rated as following:
★★★★★  specialized tarmac
★★★★  trek madone
★★★  cervelo r3
★★★  giant tcr
★★  specialized roubaix
★★  trek madone 4.5
★★  cervelo s2
★  bianchi sempre
★  scott cr1
★  scott foil
★  focus izalco
  orbea orca
  felt f5

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cannondale supersix
specialized tarmac
trek madone