The best replacement for trek madone 4.5 is specialized roubaix.

The best alternatives to trek madone 4.5 are rated as following:
★★★★★  specialized roubaix
★★★  cannondale supersix 5
★★★  felt f5
★★  specialized roubaix elite
★  scott cr1
★  giant defy composite
★  specialized roubaix comp
★  cannondale supersix

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trek madone 4.5
specialized roubaix
cannondale supersix 5