The best replacement for zed is zee.

The best alternatives to zed are rated as following:
★★★★★  zee
★★★★  talon
★★★★  akali
★★★  ziggs
★★★  fizz
★★★  katarina
★★★  yasuo
★★★  leblanc
★★  ahri
★★  gragas
★★  z
★  kayle
★  riven
★  diana
★  nidalee
★  rengar
★  renekton
★  vi
★  kassadin
★  lee sin
★  kha'zix
  lux
  heimerdinger
  mixwizard
  syndra
  ryze
  noa
  khazix
  jayce
  marcus
  swain
  elise
  nocturne
  annie
  malzahar
  vladimir
  id90
  darius
  pantheon

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Google Trends

Scale is based on the average worldwide traffic of zed in all years. Click on graph for more.
zed
zee
talon