The best replacement for virtualenv is pyenv.

The best alternatives to virtualenv are rated as following:
★★★★★  pyenv
★★★★★  vagrant
★★★★  docker
★★★★  venv
★★★  rvm
★★  virtualenvwrapper
★★  mkvirtualenv
★  pythonbrew
  buildout

Your alternative for virtualenv is not listed? Suggest!
Speaking about virtualenv, one probably shouldn't forget about pip.

Other search terms related to virtualenv and their ratings are:
★★★★★ pip
★★★★ specific python version
★★★★ pycharm
★★★ pypy
★★ anaconda
★ pydev
django
mod_wsgi
You have in mind a companion for virtualenv and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of virtualenv in all years. Click on graph for more.
virtualenv
pyenv
vagrant